高遷移率族蛋白1(HMGB1)檢測試劑盒(化學(xué)發(fā)光免疫分析法)
CLIA Kit for High Mobility Group Protein 1 (HMGB1)
HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein
- 編號(hào)USCA399Hu
- 物種Homo sapiens (Human，人) 相同的名稱，不同的物種。
- 實(shí)驗(yàn)方法雙抗夾心
- 反應(yīng)時(shí)長2h, 40min
- 檢測范圍13.7-10000pg/mL
- 靈敏度最小可檢測劑量小于等于5.1pg/mL.
- 樣本類型serum, plasma and other biological fluids
- 下載 英文說明書 中文說明書
- 規(guī)格 48T96T 96T*5 96T*10 96T*100
- 價(jià)格 ¥ 1764 ¥ 2520 ¥ 11340 ¥ 21420 ¥ 176400
- 欲了解實(shí)際交易價(jià)格和更多情況，請(qǐng)與當(dāng)?shù)亟?jīng)銷商聯(lián)系!
-
產(chǎn)品包裝(模擬)
-
產(chǎn)品包裝(模擬)
-
實(shí)驗(yàn)結(jié)果圖
-
標(biāo)準(zhǔn)曲線圖
-
通過ISO 9001、ISO 13485質(zhì)量體系認(rèn)證
特異性
本試劑盒用于檢測高遷移率族蛋白1(HMGB1)，經(jīng)檢測與其它相似物質(zhì)無明顯交叉反應(yīng)。
由于受到技術(shù)及樣本來源的限制，不可能完成對(duì)所有相關(guān)或相似物質(zhì)交叉反應(yīng)檢測，因此本試劑盒有可能與未經(jīng)檢測的其它物質(zhì)有交叉反應(yīng)。
回收率
分別于定值血清及血漿樣本中加入一定量的高遷移率族蛋白1(HMGB1)（加標(biāo)樣品），重復(fù)測定并計(jì)算其均值，回收率為測定值與理論值的比率。
| 樣本 | 回收率范圍(%) | 平均回收率(%) |
| serum(n=5) | 88-95 | 91 |
| EDTA plasma(n=5) | 96-105 | 101 |
| heparin plasma(n=5) | 80-91 | 87 |
精密度
精密度用樣品測定值的變異系數(shù)CV表示。CV(%) = SD/mean×100
批內(nèi)差：取同批次試劑盒對(duì)低、中、高值定值樣本進(jìn)行定量檢測,每份樣本連續(xù)測定20 次，分別計(jì)算不同濃度樣本的平均值及SD值。
批間差：選取3個(gè)不同批次的試劑盒分別對(duì)低、中、高值定值樣本進(jìn)行定量測定，每個(gè)樣本使用同一試劑盒重復(fù)測定8次，分別計(jì)算不同濃度樣本的平均值及SD值。
批內(nèi)差： CV<10%
批間差： CV<12%
線性
在定值血清及血漿樣本內(nèi)加入適量的高遷移率族蛋白1(HMGB1)，并倍比稀釋成1:2，1:4，1:8，1:16的待測樣本，線性范圍即為稀釋后樣本中高遷移率族蛋白1(HMGB1)含量的測定值與理論值的比率。
| 樣本 | 1:2 | 1:4 | 1:8 | 1:16 |
| serum(n=5) | 85-93% | 94-101% | 87-98% | 92-105% |
| EDTA plasma(n=5) | 85-94% | 95-102% | 90-101% | 80-101% |
| heparin plasma(n=5) | 92-103% | 85-104% | 85-95% | 83-92% |
穩(wěn)定性
經(jīng)測定，試劑盒在有效期內(nèi)按推薦溫度保存，其活性降低率小于5%。
為減小外部因素對(duì)試劑盒破壞前后檢測值的影響，實(shí)驗(yàn)室的環(huán)境條件需盡量保持一致，尤其是實(shí)驗(yàn)室內(nèi)溫度、濕度及溫育條件。其次由同一實(shí)驗(yàn)員來進(jìn)行操作可減少人為誤差。
實(shí)驗(yàn)流程
1. 實(shí)驗(yàn)前標(biāo)準(zhǔn)品、試劑及樣本的準(zhǔn)備；
2. 加樣（標(biāo)準(zhǔn)品及樣本）100µL，37°C孵育1小時(shí)；
3. 吸棄，加檢測溶液A100μL，37°C孵育1小時(shí)；
4. 洗板3次；
5. 加檢測溶液B100µL，37°C孵育30分鐘；
6. 洗板5次；
7. 加底物100µL，37°C孵育10分鐘；
8. 讀數(shù)。
實(shí)驗(yàn)原理
將高遷移率族蛋白1(HMGB1)抗體包被于96孔微孔板中，制成固相載體，向微孔中分別加入標(biāo)準(zhǔn)品或標(biāo)本，其中的高遷移率族蛋白1(HMGB1)與連接于固相載體上的抗體結(jié)合，然后加入生物素化的高遷移率族蛋白1(HMGB1)抗體，將未結(jié)合的生物素化抗體洗凈后，加入HRP標(biāo)記的親和素，再次徹底洗滌后加入底物。加入底物后會(huì)產(chǎn)生輝光型光信號(hào)。發(fā)射光強(qiáng)度和樣品中的高遷移率族蛋白1(HMGB1)呈正相關(guān)。用化學(xué)發(fā)光儀測定相對(duì)光單位（RLU），計(jì)算樣品濃度。
贈(zèng)品
增值服務(wù)
相關(guān)產(chǎn)品
| 編號(hào) | 適用物種：Homo sapiens (Human，人) | 應(yīng)用(僅供研究使用，不用于臨床診斷！) |
| UAPA399Hu02 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UEPA399Hu62 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu63 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu61 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| URPA399Hu02 | 高遷移率族蛋白1(HMGB1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UAPA399Hu64 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu61 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu62 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| UAPA399Hu63 | 高遷移率族蛋白1(HMGB1)活性蛋白 | Cell?culture;?Activity?Assays. |
| URPA399Hu01 | 高遷移率族蛋白1(HMGB1)重組蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UEPA399Hu64 | 高遷移率族蛋白1(HMGB1)真核蛋白 | Positive Control; Immunogen; SDS-PAGE; WB. |
| UPAA399Hu06 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC; IP. |
| UPAA399Hu01 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC/IF |
| UPAA399Hu02 | 高遷移率族蛋白1(HMGB1)多克隆抗體 | WB; IHC; ICC/IF |
| ULAA399Hu71 | 高遷移率族蛋白1(HMGB1)多克隆抗體(生物素標(biāo)記) | IHC |
| ULAA399Hu81 | 高遷移率族蛋白1(HMGB1)多克隆抗體(異硫氰酸熒光素標(biāo)記) | WB; IHC; ICC; IF. |
| UMAA399Hu23 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | ICC/IF |
| UMAA399Hu24 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu25 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu27 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | IHC |
| UMAA399Hu22 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | WB; ICC/IF |
| UMAA399Hu21 | 高遷移率族蛋白1(HMGB1)單克隆抗體 | WB; IHC |
| USEA399Hu | 高遷移率族蛋白1(HMGB1)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| UIEA399Hu | 高遷移率族蛋白1(HMGB1)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法,快捷型) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| UAEA399Hu | 抗高遷移率族蛋白1抗體(Anti-HMGB1)檢測試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) | Enzyme-linked immunosorbent assay for Antibody Detection. |
| USCA399Hu | 高遷移率族蛋白1(HMGB1)檢測試劑盒(化學(xué)發(fā)光免疫分析法) | Chemiluminescent immunoassay for Antigen Detection. |
| ULMA399Hu | 高遷移率族蛋白1(HMGB1)等多因子檢測試劑盒(流式熒光發(fā)光法) | FLIA Kit for Antigen Detection. |
| UKSA399Hu01 | 高遷移率族蛋白1(HMGB1)檢測試劑盒DIY材料(酶聯(lián)免疫吸附試驗(yàn)法) | 自己動(dòng)手制作ELISA試劑盒的主要材料 |
| UPGA399Hu01 | 高遷移率族蛋白1(HMGB1)引物對(duì) | PCR |
參考文獻(xiàn)
| 雜志 | 參考文獻(xiàn) |
| Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine | High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis [PubMed: PMC3094252] |
| Respiration | Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice [Karger: 000319151] |
| Surgery | Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in Southwest China [Pubmed: 22047946] |
| Viral Immunology | Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source] |
| Chinese Medical Journal | Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats [CMJ: 2009218808935901080] |
| Microbiology and Immunology | Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis [PubMed: 23278480] |
| ACTA biochimica polonica | High mobility group B1 levels in sepsis and disseminated intravascular coagulation [Actabp: Source] |
| Anesthesia and Analgesia | The Inhibitory Effect of Lidocaine on the Release of High Mobility Group Box 1 in Lipopolysaccharide-Stimulated Macrophages [PubMed: 21288974] |
| Rheumatology International | Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life [PubMed: 23143556] |
| Inflammation Research | Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279] |
| Acta Biochimica et Biophysica Sinica | IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PubMed: 22782142] |
| LabVest | The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head. [PubMed: 22825687] |
| Biomark Insights | Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism [PubMed: PMC3623607] |
| Evidence-based Complementary and Alternative Medicine | ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression [PubMed: PMC3770047] |
| Exp Ther Med | Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease [Pubmed: 23935732] |
| International of Rheumatic disesases | Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia [Pubmed: 23901875] |
| Surgery | A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034] |
| Acta Pharmacol Sin. | Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis [Pubmed: 23564080] |
| BMC pulmonary medicine | Soluble receptor for advanced glycation end-products and progression of airway disease [Pubmed: 24758342] |
| Biochemical Pharmacology | Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [Pubmed:25896849] |
| BioMed Research International | Effects of Single or Combined Treatments with Radiation and Chemotherapy on Survival and Danger Signals Expression in Glioblastoma Cell Lines [Hindawi:Source] |
| J Cardiothorac Surg. | High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study [Pubmed:Pmc4132233] |
| J Leukoc Biol. | HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells [Pubmed:24374967] |
| PLOS ONE | The Alarmin Concept Applied to Human Renal Transplantation: Evidence for a Differential Implication of HMGB1 and IL-33 [Pubmed:24586382] |
| Journal of Surgical Research | Plasma levels of high mobility group box 1 increase in patients with posttraumatic stress disorder after severe blunt chest trauma: a prospective cohort study [Pubmed:25016440] |
| Virus Research | High-mobility group box-1, promising serological biomarker for the distinction of human WNV disease severity [Pubmed:25197038] |
| Journal of Stroke and Cerebrovascular Diseases | Increased VEGF and Decreased SDF-1α in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke [Pubmed:25601176] |
| 中華臨床醫(yī)師雜志 | 高遷移率族蛋白B1和神經(jīng)元烯醇化酶對(duì)心臟驟停大鼠復(fù)蘇后腦損傷評(píng)價(jià)的研究 [Journal: Fulltext] |
| Oxidative Medicine and Cellular Longevity | Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1 [Journals: Omcl] |
| Int Immunopharmacol | Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release [PubMed: 25724384] |
| Journal of Immunotherapy | Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity [PubMed: 25962106] |
| Atherosclerosis | Retinoic acid inhibits tissue factor and HMGB1 via modulation of AMPK activity in TNF-α activated endothelial cells and LPS-injected mice [PubMed: 26116962] |
| PLOS ONE | Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China [PubMed: 26317615] |
| Int Immunopharmacol | Betulin attenuates lung and liver injuries in sepsis [PubMed: 26644168] |
| journal of cardiochoracic surgery | High mobility group box 1 gene polymorphism is associated with the risk of postoperative atrial fibrillation after coronary artery bypass surgery [PubMed: 26109393] |
| Int Immunopharmacol | Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1 [PubMed: 25812767] |
| World J Gastroenterol | Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro [PubMed: 26167076] |
| Neurotoxicology | Allopurinol reduces severity of delayed neurologic sequelae in experimental carbon monoxide toxicity in rats [PubMed: 25845300] |
| Journal of Neuroimmunology | HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis [PubMed: 25773152] |
| J Neuroinflammation | HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent [PubMed: 26394985] |
| PLoS One | Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response [PubMed: 25793984] |
| Neuroscience | Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice [PubMed: 26363151] |
| Cancer Biomarkers | Serum levels of HMGB1 have a diagnostic role in metastatic renal cell cancer [Pubmed:27062570] |
| International Immunopharmacology | Oxymatrine attenuates CCl 4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways [Pubmed:27179304] |
| SpringerPlus | Ethyl pyruvate?attenuated?coxsackievirus?B3-induced?acute?viral?myocarditis?by?suppression?ofHMGB1/RAGE/NF-ΚB?pathway. [Pubmed:27026909] |
| Acta Biochim Biophys Sin (Shanghai). | High mobility group box1 protein is involved in acute?inflammation?induced by Clostridium difficile toxin A. [content:2016] |
| United States Patent Application | COMPOSITIONS AND METHODS FOR INHIBITING HMGB1 ACTIVATION OF MELANOCYTES [y2016:0077082.html] |
| United States Patent Application | METHOD OF MAKING A SKIN CARE COMPOSITION [y2016:0077080.html] |
| Oxid Med Cell Longev. | Oxidative Stress in Metabolic Disorders: Pathogenesis, Prevention, and Therapeutics [Pubmed:26949450] |
| Oncotarget | Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors [pubmed:26980746] |
| clinical biochemistry | Relevance of pre-analytical blood management on the emerging cardiovascular protein biomarkers TWEAK and HMGB1 and on miRNA serum and plasma profiling. [pubmed:27847340] |
| disease markers | Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases. [pubmed:28348451] |
| Biogerontology. | Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. [pubmed:28316011] |
| Journal of Immunology Research | Serum HMGB1 serves as a novel laboratory indicator reflecting disease activity and [pubmed:27800496] |
| Springerplus | Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway [pubmed:27026909] |
| Molecular?Immunology | HMGB1 blockade differentially impacts pulmonary inflammation and defense responses in poly (I: C)/LPS-exposed heart transplant mice [pubmed:27387278] |
| Oxidative Medicine and Cellular Longevity | Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in … [pubmed:27833703] |
| BioMed?Research?International? | High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A [pubmed:27579314] |
| Cardiology | The role of high mobility group box 1 protein in interleukin-18-induced myofibroblastic transition of valvular interstitial cells [pubmed:27395056] |
| Innate?immunity | HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production [pubmed:27670944] |
| Urolithiasis. | Urinary?MCP-1、HMGB1?increased?in?calcium?nephrolithiasis?patients?and the?influence?ofhypercalciuria?on the?production?of the?two?cytokines. [pubmed:27393275] |
| Journal?of?Investigative?Surgery | Diagnostic?Value?of?High-Mobility Group Box 1?(HMGB1)?Protein?in?Acute?and?Perforated Appendicitis. [pubmed:27922766] |
| J Cell Biochem | High Mobility Group Box 1 Mediates Interferon-r-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells. [pubmed:27579780] |
| BMC Vet Res. | Blood markers of fibrinolysis and endothelial activation in canine babesiosis. [pubmed:28363279] |
| Immunol Res. | Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. [pubmed:28108937] |
| Biomed Pharmacother. | SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. [pubmed:28122311] |
| Sci Rep.? | Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats. [pubmed:28373667] |
| Integrative Cancer Science and Therapeutics | The expression of HMGB1 and the receptor for advanced glycation end products (RAGE) in epithelial ovarian cancer [pdf:ICST-4-232.pdf] |
| Journal of Food and Drug Analysis | Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of?Cinnamomum osmophloeum?Kanehira in endotoxin-induced … [S1021-9498(17)30081-9] |
| Biomedicine & Pharmacotherapy | SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death [DOI:10.1016/j.biopha.2017.01.087] |
| Stem Cell Rev and Rep | Induction of?Immunogenic Cell Death in?Lymphoma Cells by?Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium [pubmed:28918474] |
| Scientific Reports COMMUNICATIONS | Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1 [pubmed:29192209] |
| Biochemical and Biophysical Research Communications | Oxidized low-density lipoprotein promotes osteoclast differentiation from CD68 positive mononuclear cells by regulating HMGB1 release [pubmed:29146189] |
| Pulmonary Pharmacology & Therapeutics | HMGB1 promotes HLF-1 proliferation and ECM production through activating HIF1-a-regulated aerobic glycolysis [pubmed:28571757] |
| Biomedical Research | Correlation between high mobility group box 1 protein, tumor necrosis factor-α, and acute coronary syndrome [ISSN 0970-938X] |
| Molecular Cancer | PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy [pubmed:28499449] |
| BMC Complementary and Alternative Medicine | Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times. [pubmed:29258482] |
| 25 | Blocking the Feedback Loop between Neuroendocrine Differentiation and Macrophages Improves the Therapeutic Effects of Enzalutamide (MDV3100) on Prostate Cancer. [pubmed:29191973] |
| Nature microbiology | Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection. [pubmed:27748732] |
| Cellular physiology and biochemistry | Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide. [pubmed:28662496] |
| Molecular Medicine Reports | Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury [pubmed:28627643] |
| Cell?Death?&?Disease | AMP-activated protein kinase agonist N 6-(3-hydroxyphenyl) adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis [Articles:s41419-017-0118-0] |
| Journal of Molecular?Cell?Biology | S1 PR 3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen‐glucose deprivation‐induced neuroinflammation via inhibiting TLR 2/4‐NF κB?… [Pubmed:29536648] |
| Frontiers in Immunology | Glycyrrhizin Protects Mice against Experimental Autoimmune Encephalomyelitis by Inhibiting HMGB1 Expression and Neuronal HMGB1 Release [Pubmed:30013568] |
| Oncoimmunology | Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune?… [Pubmed:29399399] |
| Cancer Immunology, Immunotherapy | Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer [Pubmed:29600445] |
| Cytokine | Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in?… [Pubmed:29895396] |
| Frontiers in Neurology | Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB?… [Pubmed:29867706] |
| Biomedicine & Pharmacotherapy | Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death [Pubmed:29958141] |
| Inflammation?Research | Luteolin activates ERK1/2- and Ca-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and?… [Pubmed:29497773] |
| Journal of?Food?and?Drug?Analysis | Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice [Pubmed:29389558] |
| Biochemical and Biophysical?Research?Communications | Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice [Pubmed:29680657] |
| Neurological Sciences | Thrombomodulin, alarmin signaling, and copeptin: cross-talk between obesity and acute ischemic stroke initiation and severity in Egyptians [Pubmed:29637447] |
| International Journal of Gynecology & Obstetrics | Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia [Pubmed:29569400] |
| Advances in Experimental?Medicine?and?Biology | Molecules of Damage-Associated Patterns in Bronchoalveolar Lavage Fluid and Serum in Chronic Obstructive Pulmonary Disease [Pubmed:29429028] |
| Taiwanese Journal of Obstetrics & Gynecology | HMGB1-RAGE signaling pathway in pPROM [Pubmed:29673663] |
| Chronic obstructive pulmonary disease (COPD)--from biomarkers to clinical phenotypes [ISBN:978-951-51-4039-5] | |
| Journal?of?Pharmacological?Sciences | Butyrate suppresses abnormal proliferation in colonic epithelial cells under diabetic state by targeting HMGB1 [Doi: 10.1016/j.jphs.2018.07.012] |
| Biomaterials Science | Delivery of 5'-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer Immunotherapy [Doi: 10.1039/C8BM01064A?] |
| iris-AperTO [] | |
| Toxicological Sciences | Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation [Pubmed: 31020321] |
| Molecular Medicine | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic?… [Pubmed: 31215394] |
| international immunopharmacology | Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes [Pubmed: 31185450] |
| Food & Function | Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats [Pubmed: 31140472] |
| International Immunopharmacology | BET bromodomain inhibitor JQ1 promotes immunogenic cell death in tongue squamous cell carcinoma [Pubmed: 31600692] |
| Experimental and Therapeutic Medicine | High mobility group box protein 1 neutralization therapy in ovine bacteremia: Lessons learned from an ovine septic shock model incorporating intensive care support [Pubmed: 31602200] |
| Oxidative Medicine and Cellular Longevity | Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin E Administration on Clinical, Metabolic, Endothelial Dysfunction, Oxidative Stress Parameters?… [Pubmed: 31737175] |
| Pathobiology | Magnetic hyperthermia using self-controlled heating elements consisting of Fe-Al milling alloy induces cancer cell apoptosis while preserving skeletal muscle [Pubmed: 31722347] |
| Canadian Journal of Physiology and Pharmacology | Suppression of high-mobility group box 1 ameliorates xerostomia in a sjogren syndrome-triggered mouse model [Pubmed: 31935120] |
| Neurotoxicity Research | HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway [Pubmed: 31858421] |
| Journal of Clinical Medicine | Damage-Associated Molecular Patterns and Th-Cell-Related Cytokines Released after Progressive Effort [Pubmed: 32210109] |
| Journal of Immunology Research | Dendritic Cells Loaded with Heat Shock-Conditioned Ovarian Epithelial Carcinoma Cell Lysates Elicit T Cell-Dependent Antitumor Immune Responses In Vitro [Pubmed: 31886313] |
| urologic oncology | A novel diagnostic tool for the detection of bladder cancer: Measurement of urinary high mobility group box-1 [Pubmed: 32312640] |
| International Journal of Environmental Research and Public Health | Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent [Pubmed: 32316587] |
| VETERINARY MICROBIOLOGY | Upregulation of HMGB1 Secretion in Lungs of Pigs Infected by Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus [Pubmed: 33221069] |
| Lab Invest | Extracellular cold-inducible RNA-binding protein regulates neutrophil extracellular trap formation and tissue damage in acute pancreatitis [Pubmed: 32709888] |
| American Journal of Translational Research | Inhibition of calpain alleviates coxsackievirus B3-induced myocarditis through suppressing the canonical NLRP3 inflammasome/caspase-1-mediated and … [Pubmed: 32509190] |
| STEM CELL REVIEWS AND REPORTS | A Novel Evidence That Mannan Binding Lectin (MBL) Pathway of Complement Cascade Activation is Involved in Homing and Engraftment of Hematopoietic Stem … [Pubmed: 32406006] |
| Translational Stroke Research | Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting?… [] |
| stem cells international | Hypoxic Wharton's Jelly Stem Cell Conditioned Medium Induces Immunogenic Cell Death in Lymphoma Cells [] |
| Frontiers in Cell and Developmental Biology | Aberrant Expression of High Mobility Group Box Protein 1 in the Idiopathic Inflammatory Myopathies [] |
| Naja sumatrana venom cytotoxin, sumaCTX exhibits concentration-dependent cytotoxicity via caspase-activated mitochondrial-mediated apoptosis without?… [] | |
| Journal of Burn Care & Research | Umbilical cord mesenchymal stem cells (hUCMSCs) for inflammatory regulation after excision and grafting of severe burn wounds in rats [33313794] |
| Cell Death & Disease | DAMPs released by pyroptotic cells as major contributors and therapeutic targets for CAR-T-related toxicities [33504767] |
| Cells | Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death [32331368] |
| Infect Immun | A non-lethal murine flame burn model leads to a transient reduction in host defenses and enhanced susceptibility to lethal Pseudomonas aeruginosa infection [34152806] |
| Inhaled [D-Ala2]-Dynorphin 1-6 Prevents Hyperacetylation and Release of High Mobility Group Box 1 in a Mouse Model of Acute Lung Injury [34616852] | |
| Mol Cell Biochem | Autophagy-associated HMGB-1 as a novel potential circulating non-invasive diagnostic marker for detection of Urothelial Carcinoma of Bladder [34796446] |
| World J Gastroenterol | Calycosin attenuates severe acute pancreatitis-associated acute lung injury by curtailing high mobility group box 1-induced inflammation [34908806] |
| Endocr J | Clinical significance of high mobility group box 1/toll-like receptor 4 in obese diabetic patients [34657898] |
| Research in Veterinary Science | Choline or CDP-choline restores hypotension and improves myocardial and respiratory functions in dogs with experimentally–Induced endotoxic shock [34715589] |
| Sci Rep | Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells [Pubmed:35058496] |
| ORL J Otorhinolaryngol Relat Spec | High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis [Pubmed:34979505] |
| J Exp Clin Cancer Res | SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma [Pubmed:35197103] |
| Am J Physiol Gastrointest Liver Physiol | Abnormal intestinal milieu in post-traumatic stress disorder is not impacted by treatment that improves symptoms [Pubmed:35638693] |
| Journal of the South African Veterinary Association | Circulating markers of endothelial activation in canine parvoviral enteritis [] |
| Reseach square | The antiviral action of resveratrol against Zika virus through the regulation of interferon responses by HMGB1 [] |
留言咨詢
